Epithelioid Sarcoma and Unclassified Sarcoma with Epithelioid Features: Clinicopathological Variables, Molecular Markers, and a New Experimental Model

摘要

This study aims to address the current knowledge gap in the diagnosis and treatment of epithelioid sarcoma (ES) and unclassified sarcoma with epithelioid features (USEF) by: (a) characterizing and comparing the clinical behavior and outcome of ES and USEF patients treated at a single institution, (b) evaluating the expression of a panel of differentiation and other tumor-related molecular markers in human ES and USEF specimens, and (c) developing an ES experimental model for future studies to enhance our understanding of ES molecular determinants while developing more effective therapeutic strategies.